Anti-inflammatory agent 49_product_DataBase

Bioactivity	nti-inflammatory agent 49 (compound SC9) is a quite potent and selective inhibitor of Drp1-Fis1 interaction and can reduce FIS1-mediated mitochondrial dysfunction. The IC50 of SC9 inhibiting GTPase in vitro is 270 nM[1].
Target	IC50: 270 nM (dynamin-related protein 1 ,Drp1 )
Invitro	1.Anti-inflammatory agent 49 降低LPS (HY-D1056) 诱导的H9c2 细胞线粒体功能障碍，可拯救 LPS 诱导的小鼠内毒素血症。2.Anti-inflammatory agent 49 可抑制LPS 处理后Drp1 的产生及Drp1- fis1 的相互作用。 Cell Viability Assay Cell Line:
In Vivo	Anti-inflammatory agent 49 (10 mg/kg，每 8 小时一次，持续 72 小时）可治疗小鼠 LPS 诱导的内毒素血症[1]。 Animal Model:
Name	Anti-inflammatory agent 49
CAS	851471-44-8
Formula	C21H22N8O3S
Molar Mass	466.52
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Luis Rios, et al. Targeting an allosteric site in dynaminrelated protein 1 to inhibit Fis1-mediated mitochondrial dysfunction. Nat Commun. 2023 Jul 19;14(1):4356

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