Anti-inflammatory agent 40

CAS: F: C30H24Cl2N2O4 W: 547.43

Anti-inflammatory agent 40 is a potential anti-malarial and anti-inflammatory agent. Anti-inflammatory agent 40 inhibi

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Bioactivity	Anti-inflammatory agent 40 is a potential anti-malarial and anti-inflammatory agent. Anti-inflammatory agent 40 inhibits carrageenan induced paw swelling in vivo[1].
Invitro	Anti-inflammatory agent 40 对恶性疟原虫 CQ 敏感株和耐药株均有抑制作用，Anti-inflammatory agent 40 对氯喹敏感株 P. falciparum (Pf3D7) 的 IC50 值为 1.47 μM。Anti-inflammatory agent 40 抑制 LPS 诱导的 MAP 激酶活化，降低 pERK1/2 (Thr202/Tyr204) 和 pJNK1/2 的表达在 THP-1 单核细胞[1]。
In Vivo	Anti-inflammatory agent 40 (p.o, 1 h prior to caraageenan injection；25, 50 and 100 mg/kg；Paw swelling was subsequently monitored after 4 and 6) shows inhibition in swiss mice, the Carrageenan inhibition percent are 61%, 56% at 25mg/kg after 4h or 6h, respectively. the Carrageenan inhibition percent are 62%, 56% at 50 mg/kg after 4h or 6h, respectively, and 73%, 65% at 50 mg/kg after 4h or 6h, respectively [1].Anti-inflammatory agent 40 exhibits good PK profile, it is satisfactory and can be attested for the candidates for future drug discovery optimization, the Cmax, Tmax, AUC, t1/2 are 110.37 ± 11.92 ng/mL, 0.25 ± 0.0 h, 86.91 ± 16.86 h.ng/mL and 0.87 ± 0.15 h, respectively[1].
Name	Anti-inflammatory agent 40
Formula	C30H24Cl2N2O4
Molar Mass	547.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Alka Raj Pandey, et al. Design, synthesis and evaluation of novel pyrrole-hydroxybutenolide hybrids as promising antiplasmodial and anti-inflammatory agents. Eur J Med Chem. 2023 Jun 5;254:115340