| Bioactivity | Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory agent 15 inhibits Mtb H37Rv and M299 growth, with MIC50 (minimum inhibitory concentration 50%) of 2.3 and 7.8 μM, respectively. Anti-inflammatory agent 15 inhibits NO through the suppression of iNOS expression, and also inhibited the production of TNF-α and IL-1β. Anti-inflammatory agent 15 can be used for tuberculosis (TB) research[1]. |
| Target | MIC50: 2.3 ± 1.6 μM (Mtb H37Rv), 7.8 ± 0.8 μM (Mtb M299); IC50: 2.4 ± 0.4 μM (NO) |
| Invitro | Anti-inflammatory agent 15 (compound 29) is active in the reduction of accumulated nitrite, with an IC50 of 71.7 ± 1.1 μM[1]. |
| Name | Anti-inflammatory agent 15 |
| CAS | 474516-87-5 |
| Formula | C17H20N2S |
| Molar Mass | 284.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Calixto SD, et al. Antimycobacterial and anti-inflammatory activities of thiourea derivatives focusing on treatment approaches for severe pulmonary tuberculosis. Bioorg Med Chem. 2022 Jan 1;53:116506. |
Anti-inflammatory agent 15
CAS: 474516-87-5 F: C17H20N2S W: 284.42
Anti-inflammatory agent 15 (compound 29) is a potent antimycobacterial and anti-inflammatory agent. Anti-inflammatory ag
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.