Anti-MRSA agent 11_product_DataBase

Bioactivity	Anti-MRSA agent 11 suppresses fluoroquinolone-sensitive strain USA500 and -resistant MRSA isolate Mu50 (MIC =0.39 μg/mL). Anti-MRSA agent 11 displayes favorable in vivo half-life and safety profiles[1].
Invitro	Anti-MRSA agent 11 (100 μM； 24 h) 对 A549 细胞和 HEK-293 细胞均无细胞毒性, Anti-MRSA agent 11对细菌细胞具有高度选择性毒性[1]。Anti-MRSA agent 11 (0.25 μg/ml ；培养 15 代) 对 MRSA 菌株 ATCC33591 有持久的抗菌活性[1]。Anti-MRSA agent 11 能够通过细菌的细胞膜，尤其是革兰氏阴性菌的外膜，进入细菌内部发挥作用[1]。Anti-MRSA agent 11 抑制细菌的拓扑异构酶 IV ，从而干扰细菌的遗传物质传递过程[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anti-MRSA agent 11 相关抗体:
In Vivo	Anti-MRSA agent 11 (0，400， 1000 和 2000 mg/kg，灌胃；持续8天 ) 没有显著影响小鼠的体重和食物摄入量[1]。药代动力学分析于雄性SD大鼠模型中[1]Route
CAS	3029704-83-1
Formula	C24H18F2N4O3
Molar Mass	448.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hongxue Dai,et al. Identification of CH2-linked quinolone-aminopyrimidine hybrids as potent.

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