Anti-MRSA agent 10_product_DataBase

Bioactivity	Anti-MRSA agent 10 (Compound 2d) is a Cephalosporin (HY-144229) derivative and exhibits antibacterial activity. Anti-MRSA agent 10 is slightly drug resistane and exhibits low cytotoxicity in cells HUVEC and HBZY-1[1].
Invitro	Anti-MRSA agent 10 对绵羊红细胞，HUVECs 和 HBZY-1 cells 无明显细胞毒性，安全剂量大于 128 μg/mL[1]。Anti-MRSA agent 10 对革兰氏阴性 Stenotrophomonas maltophilia 和 Staphylococcus aureus，革兰氏阳性 Escherichia coli 和 Stenotrophomonas maltophilia，以及抗药性 Staphylococcus aureus (MRSA) 具有抗菌活性，MIC 分别为 0.7，4，8，8 和 2-4 μg/mL[1]。Anti-MRSA agent 10 (0-128 μg/mL) 通过靶向青霉素结合蛋白 (PBP)，破坏细菌细胞壁结构并促进氧化损伤抑制细菌 S. aureus 的细胞呼吸和活力[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Anti-MRSA agent 10 相关抗体: Cell Viability Assay[1] Cell Line:
Formula	C30H36F3N7O8S2
Molar Mass	743.77
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chen S, et al., Design, synthesis and antibacterial evaluation of low toxicity amphiphilic-cephalosporin derivatives. Eur J Med Chem. 2024 Mar 15;268:116293.

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