| Bioactivity | 1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg/mL[1]. 1-Hydroxyphenazine exhibits anticancer and anti-inflammatory activity against cells A549, 1321N1 and RAW264.7, antifungal and antibacterial activity against strains Candida albicans, Aspergillus fumigatus, Escherichia coli and Xanthomonas campestris[2][3][4][5]. |
| Invitro | 1-Hydroxyphenazine (0.1-100 μM) 过形成酸性囊泡细胞器 (细胞自噬的标志) 抑制脑星形细胞瘤 1321N1 细胞的增殖，对中枢神经系统 (CNS) 表现出潜在毒性[2]。Hydroxyphenazine (0-10 μg/mL) 可抑制 TNF-α 的分泌和 M1 细胞极化，抑制 LPS 诱导的 RAW264.7 细胞炎症，且无明显毒性[3]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 1-Hydroxyphenazine 相关抗体: Cell Proliferation Assay[3] Cell Line: |
| CAS | 528-71-2 |
| Formula | C12H8N2O |
| Molar Mass | 196.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nguyen TH, et al., Novel α-Amylase Inhibitor Hemi-Pyocyanin Produced by Microbial Conversion of Chitinous Discards. Mar Drugs. 2022 Apr 23;20(5):283. [2]. McFarland AJ, et al., Inhibition of autophagy by 3-methyladenine protects 1321N1 astrocytoma cells against pyocyanin- and 1-hydroxyphenazine-induced toxicity. Arch Toxicol. 2012 Feb;86(2):275-84 [3]. Xiao J, et al., Anti-Inflammatory Effects of an Extract from Pseudomonas aeruginosa and Its Purified Product 1-Hydroxyphenazine on RAW264.7 Cells. Curr Microbiol. 2021 Jul;78(7):2762-2773. [4]. Prabhu MS, et al., Purification and molecular and biological characterisation of the 1-hydroxyphenazine, produced by an environmental strain of Pseudomonas aeruginosa. World J Microbiol Biotechnol. 2014 Dec;30(12):3091-9. [5]. Kerr JR, et al., Pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine inhibit fungal growth. J Clin Pathol. 1999 May;52(5):385-7. |
1-Hydroxyphenazine
CAS: 528-71-2 F: C12H8N2O W: 196.20
1-Hydroxyphenazine (Hemipyocyanine; 1-Phenazinol; Hemi-pyocyanin) is an inhibitor for α-Amylase with an IC50 of 3.1 μg
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