| Bioactivity | Angiotensin II (3-8), human (TFA) is a less effective agonist at the angiotensin AT1 receptor. | ||||||
| Target | Angiotensin AT1 receptor. | ||||||
| In Vivo | Human Angiotensin II (3-8) causes endothelium-dependent renal cortical vasodilatation, in anaesthetized rats. At doses up to 125 pmol/kg, human Angiotensin II (3-8) is without any cardiovascular effects, but with doses of 1.25 and 12.5 nmol/kg there are dose-dependent increases in mean arterial blood pressure and reductions in renal and mesenteric flows and vascular conductances[1]. | ||||||
| Name | Angiotensin II (3-8), human TFA | ||||||
| Formula | C42H55F3N8O10 | ||||||
| Molar Mass | 888.93 | ||||||
| Appearance | Solid | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Gardiner SM, et al. Regional haemodynamic effects of angiotensin II (3-8) in conscious rats. Br J Pharmacol. 1993 Sep;110(1):159-62. |