| Bioactivity | Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory mediators from leukocytes. Alclometasone can be used to relieve corticosteroid-responsive dermatoses, including atopic dermatitis, eczema, psoriasis and allergic dermatitis[1]. |
| Target | IC50: glucocorticoid receptor |
| In Vivo | The prodrug of alclometasone is alclometasone dipropionate[2].Alclometasone dipropionate (subcutaneous injection; 1 % (w/v) arabic gum; 2 weeks) inhibits the activity of androgen-dependent cytochrome P450 and O-depropylation activity as a dose-dependent manner in male Slc-Wistar strain rats. However, it has no effects on hepatic drug metabolism in female rats or DS strain mice[2]. |
| Name | Alclometasone |
| CAS | 67452-97-5 |
| Formula | C22H29ClO5 |
| Molar Mass | 408.92 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Alclometasone [2]. Nishibe Y, et al. Species and sex differences in the inhibitory action of the corticosteroid alclometasone dipropionate on the hepatic drug-metabolizing system.Jpn J Pharmacol. 1989 Aug;50(4):435-43. |
Alclometasone
CAS: 67452-97-5 F: C22H29ClO5 W: 408.92
Alclometasone (7a-Chloro-16a-methyl prednisolone) is a glucocorticoid and inhibits the release of pro-inflammatory media
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