Ailanthoidol

CAS: 156398-61-7 F: C19H18O5 W: 326.34

Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopr

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Bioactivity	Ailanthoidol is a natural occurring neolignan, with anti-inflammatory and antitumor activities. Ailanthoidol has chemopreventive activity against tumor promotion[1][2].
Invitro	Ailanthoidol (20 μM; 24-72 hours) showed no cytotoxicity toward RAW264.7 macrophages[1]. Ailanthoidol (1.25-20 μM; 24 hours) suppresses the generation of nitric oxide (NO) and prostaglandin E2 , aswell as theexpression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 induced by lipopolysaccharide (LPS) in RAW264.7 cells[1].Ailanthoidol (1.25-20 μM; 24 hours) inhibits the production of inflammatory cytokines induced by LPS in RAW264.7 cells, including interleukin (IL)-1b and IL-6[1].Ailanthoidol suppresses NF-kB activation by blocking Ik-Ba degradation[1]. Western Blot Analysis[1] Cell Line:
In Vivo	Ailanthoidol (0.1-10 mg/kg; i.g.; 24 hours and 1 hours before LPS was injected, for 5 days) protects BALB/c mice from LPS (25mg/kg)-induced endotoxin shock, possibly through inhibition of the production of inflammatory cytokines and NO[1]. Animal Model:
Name	Ailanthoidol
CAS	156398-61-7
Formula	C19H18O5
Molar Mass	326.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jin-Kyung Kim, et al. Ailanthoidol suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice. J Cell Biochem. 2011 Dec;112(12):3816-23. [2]. Yean-Jang Lee, et al. Inhibitory effect of ailanthoidol on 12-O-tetradecanoyl-phorbol-13-acetate-induced tumor promotion in mouse skin. Oncol Rep. 2006 Oct;16(4):921-7.