| Bioactivity | Acyclovir (Aciclovir) is a potent, orally active antiviral agent. Acyclovir has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir induces cell cycle perturbation and apoptosis. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia[1][2][3][4]. | ||||||||||||
| Invitro | Acyclovir (Aciclovir, 3-100 µM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent[1].Acyclovir (Aciclovir, 10-100 µM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner[1].Acyclovir (Aciclovir, 10-100 µM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation[1]. Cell Viability Assay[1] Cell Line: | ||||||||||||
| Name | Acyclovir | ||||||||||||
| CAS | 59277-89-3 | ||||||||||||
| Formula | C8H11N5O3 | ||||||||||||
| Molar Mass | 225.20 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|