| Bioactivity | Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL[1]. | ||||||||||||
| Invitro | Fluconazole inhibits 4 species ofAspergillus fumigatus with the IC50s of 23.9-43.5 μg/mL. Fluconazole (0.20 μg/mL) inhibits significantly the mycelial-phase growth and germ tube elongation of C. albicans in a medium supplemented with serum[1]. Fluconazole is a triazole antifungal agent that has been available for the treatment of infections due to Candida, Cryptococcus. The MIC90 is highest for C. krusei (MIC ≥ 64 μg/mL) and C. glabrata (MIC, 32 μg/mL) and is ≤2 μg/mL for C. albicans (0.5 μg/mL), C. parapsilosis (2 μg/mL), C. tropicalis (2 μg/mL), C. lusitaniae (2 μg/mL), and C. kefyr (0.5 μg/mL)[2].Fluconazole (0.1-50.0 μg/mL) damages the fungal cells and reduces their viability[3]. Cell Viability Assay[3] Cell Line: | ||||||||||||
| Name | Fluconazole | ||||||||||||
| CAS | 86386-73-4 | ||||||||||||
| Formula | C13H12F2N6O | ||||||||||||
| Molar Mass | 306.27 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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Fluconazole
CAS: 86386-73-4 F: C13H12F2N6O W: 306.27
Fluconazole (UK-49858) is a triazole antifungal agent with excellent activities against a broad range of fungi, especial
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