| Bioactivity | Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km = 1,570 mM-1s-1), and can be used for detection of proteinase 3 (PR3) activity[1][2]. |
| CAS | 1042405-14-0 |
| Sequence | {Abz}-Val-Ala-Asp-{Nva}-Arg-Asp-Arg-Gln-{EDDnp} |
| Shortening | {Abz}-VAD-{Nva}-RDDQ-{EDDnp} |
| Formula | C53H80N20O18 |
| Molar Mass | 1285.33 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yu J, et al. Cathepsin C from extracellular histone-induced M1 alveolar macrophages promotes NETosis during lung ischemia-reperfusion injury. Redox Biol. 2024 Jun 6;74:103231. [2]. Korkmaz B, et al. Measurement of neutrophil elastase, proteinase 3, and cathepsin G activities using intramolecularly quenched fluorogenic substrates. Methods Mol Biol. 2012;844:125-38. |
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp
CAS: 1042405-14-0 F: C53H80N20O18 W: 1285.33
Abz-Val-Ala-Asp-Nva-Arg-Asp-Arg-Gln-EDDnp is a fluorescence-quenched peptide substrate for human proteinase 3 (kcat/Km =
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