| Bioactivity | AZD1092 is an orally active glucokinase (GK) activator with an EC50 value of 0.03 μM. AZD1092 can be used for the research of Type 2 Diabetes (T2D)[1]. |
| Target | EC50: 0.03 μM (glucokinase) |
| Invitro | AZD1092 对葡萄糖激酶具有活性，EC50 值为 0.03 μM[1]。 |
| In Vivo | AZD1092 (oral; 1, 3, 10 mg/kg) 呈剂量依赖性降低 Zucker 大鼠血糖波动，具有降糖作用[1]。 Animal Model: |
| Name | AZD1092 |
| CAS | 871656-65-4 |
| Formula | C24H26N4O5 |
| Molar Mass | 450.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Michael J. Waring, et al. Matrix-based multiparameter optimisation of glucokinase activators: the discovery of AZD1092. Med. Chem. Commun., 2011, 2, 775. |