| Bioactivity | ATM Inhibitor-8 (Compound 10r) is a highly potent, selective and orally active ATM inhibitor,with an IC50 of 1.15 nM. ATM Inhibitor-8 exhibits anti-tumor activity[1]. |
| Target | IC50:1.15 nM (ATM) |
| Invitro | ATM Inhibitor-8 对结直肠癌细胞 (HCT116、SW620) 和乳腺癌细胞 (MCF-7) 的有抑制作用[1]。ATM Inhibitor-8 (200 nM) 联合 4.22 μM Etposide (HY-13629) 和0.036 μM Irinotecan (HY-16562) 可抑制 MCF-7 细胞活率[1]。ATM Inhibitor-8 (200 nM) 联合 0.22 μM Irinotecan 可降低 SW620 细胞活率同时抑制 SW620 细胞克隆形成 (0.02 μM)[1]。 Western Blot Analysis Cell Line: |
| In Vivo | ATM Inhibitor-8 联合 Irinotecan (40 mg/kg) (HY-16562) 对 SW620 小鼠模型肿瘤生长的抑制作用[1]。ATM Inhibitor-8 (10 mg/kg, i.v.) 在 Balb/c 小鼠中具有良好的 PK 值，这意味着较低的血浆清除率、较高的血浆暴露以及优异的口服生物利用度。[1]。 Animal Model: |
| Name | ATM Inhibitor-8 |
| Formula | C26H34N6O2 |
| Molar Mass | 462.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. D Deng, et al. Discovery and Evaluation of 3-Quinoxalin Urea Derivatives as Potent, Selective, and Orally Available ATM Inhibitors Combined with Chemotherapy for the Treatment of Cancer via Goal-Oriented Molecule Generation and Virtual Screening. J Med Chem. 2023 Jul 27， |