| Bioactivity | ATF3 inducer 1 is a potent ATF3 inducer. ATF3 inducer 1 increases the ATF3 protein and ATF3 mRNA expression. ATF3 inducer 1 shows anti-MetS activity in mouse[1]. |
| Invitro | ATF3 inducer 1 (compound 16c) (50 μM; 8 days) 增加 3T3-L1 细胞中的 ATF3 蛋白和 ATF3 mRNA 表达[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | ATF3 inducer 1 (40 mg/kg; i.p.; three times a week for 10-weeks) 在小鼠体内显示出抗 MetS (管理代谢综合征) 活性[1]。 Animal Model: |
| Name | ATF3 inducer 1 |
| Formula | C12H10N2O3 |
| Molar Mass | 230.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chang YH, et al. Exploration and biological evaluation of 7-methoxy-3-methyl-1H-chromeno[4,3-c]pyrazol-4-one as an activating transcription factor 3 inducer for managing metabolic syndrome. Eur J Med Chem. 2022 Nov 25;246:114951. |