| Bioactivity | AT-0174 is an orally active dual inhibitor of IDO1/TDO2 with IC50 values of 0.17 and 0.25 μM, respectively. AT-0174 has antitumor activity[1][2]. |
| Invitro | AT-0174 (170 mg/kg/day, 口服, 连续 15 天) 可抑制非小细胞肺癌异体移植小鼠的肿瘤生长[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AT-0174 相关抗体: |
| Formula | C6H5ClFN3O |
| Molar Mass | 189.57 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Crump LS, et al. Targeting tryptophan catabolism in ovarian cancer to attenuate macrophage infiltration and PD-L1 expression. Cancer Res Commun. 2024 Mar 7. [2]. Wu C, et al. Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer. Cancer Metab. 2023 May 24;11(1):7. |