| Bioactivity | ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle regulating kinases. ASK1-IN-3 has strong HepG2 cancer cells apoptosis induction and potent cell cycle arrest activities[1]. |
| Invitro | ASK1-IN-3 (compound 14l) (10, 20 and 50 μM; 48 hours) induces PARP cleavage in a dose dependent manner, which indicates the induction of HepG2 cells apoptosis[1].ASK1-IN-3 (1-16 μM; 24 hours) significantly arrests cycle progression at G1 phase[1]. Apoptosis Analysis Cell Line: |
| Name | ASK1-IN-3 |
| CAS | 2426705-19-1 |
| Formula | C18H18N8O2 |
| Molar Mass | 378.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
ASK1-IN-3
CAS: 2426705-19-1 F: C18H18N8O2 W: 378.39
ASK1-IN-3 is a potent and selective ASK1 kinase inhibitor with IC50 of 33.8 nM, as well as inhibits several cell cycle r
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