| Bioactivity | AR antagonist 8 (compound 16) is a potent Lupeol-inspired androgen receptor (AR) antagonist with an IC50 of 0.76 μM. AR antagonist 8 is a uniquely substituted unnatural entestrane[1]. |
| Formula | C22H32O |
| Molar Mass | 312.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zachary D Stempel, et al. Function-Oriented Synthesis of Pentacyclic Triterpenoids and Discovery of an ent-Estrane as a Natural Product-Inspired Androgen Receptor Antagonist. Org Lett. 2024 Apr 19;26(15):3054-3059. |