| Bioactivity | APX879 is a fungal-specific calcineurin inhibitor that has less immunosuppressive activities and toxicities. APX879 is a C22-modified FK506 (HY-13756) analog, which maintains broad-spectrum antifungal activity[1][2]. |
| CAS | 1801372-27-9 |
| Formula | C46H73N3O12 |
| Molar Mass | 860.08 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Gobeil SM, et al. Leveraging Fungal and Human Calcineurin-Inhibitor Structures, Biophysical Data, and Dynamics To Design Selective and Nonimmunosuppressive FK506 Analogs. mBio. 2021 Dec 21;12(6):e0300021. [2]. Hoy M J. Development of Novel Antifungal Compounds for the Treatment of Systemic Fungal Infections[D]. Duke University, 2022. |