| Bioactivity | AN11251 is a potent and oral active anti-Wolbachia agent with potential for treatment of onchocerciasis and lymphatic filariasis, with EC50 values of 1.5 nM in LDW1 cell lines and 15 nM in C6/36 cell lines[1]. |
| In Vivo | AN11251 (25 mg/kg, PO, BID for 7 or 14 days) reduces the Wolbachia load in the B. malayi larvae by 75.4% and 98.8% in the 7- and 14-day treatment groups, respectively[1]. Animal Model: |
| Name | AN11251 |
| CAS | 2130750-59-1 |
| Formula | C29H38BFO7 |
| Molar Mass | 528.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jacobs RT, et al. Boron-Pleuromutilins as Anti- Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis. J Med Chem. 2019 Mar 14;62(5):2521-2540. |