| Bioactivity | AN-3485 is a benzoxaborole analog, Toll-Like Receptor(TLR) inhibitor with IC50 values ranging from 18 to 580 nM. | ||||||||||||
| Target | IC50：AN-3485 inhibits TLR2-, TLR3-, TLR4-, and TLR5-mediates TNF-a, IL-1b, and IL-6 release with IC50 values of human PBMCs (103±68 nM, 68±63 nM, 72±33 nM)and isolated monocytes (77±26 nM; 18±6.7 nM; 32±6.5 nM) . | ||||||||||||
| Name | AN-3485 | ||||||||||||
| CAS | 1213827-99-6 | ||||||||||||
| Formula | C14H13BClNO3 | ||||||||||||
| Molar Mass | 289.52 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Dong C, et al. Inhibition of Toll-like receptor-mediated inflammation in vitro and in vivo by a novelbenzoxaborole. J Pharmacol Exp Ther. 2013 Feb;344(2):436-46. |