AMPK-IN-1_product_DataBase

Bioactivity	AMPK-IN-1 is an activator of AMPK (EC50: 551 nM for isoform α2β2γ1). AMPK-IN-1 leads to eEF2 phosphorylation in a mTORC1-independent way[1][2][3].
Invitro	AMPK-IN-1 (Compound 991) (5 μM, 60 min) 诱导离体小鼠滑车上肌中乙酰辅酶 A 羧化酶 (ACC) 的磷酸化[1]。AMPK-IN-1 (0-10 μM，60 分钟) 在 MEF 细胞中诱导 eEF2 磷酸化，并且不依赖于 mTORC1[1]。 Western Blot Analysis[1] Cell Line:
Name	AMPK-IN-1
CAS	1219739-95-3
Formula	C24H18ClN3O3
Molar Mass	431.87
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ngoei KRW, et al. Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4. Cell Chem Biol. 2018 Jun 21;25(6):728-737.e9. [2]. Cao Y, et al. Novel cyclic benzimidazole derivatives useful anti-diabetic agents. Patent. WO2010036613. [3]. Johanns M, et al. Direct and indirect activation of eukaryotic elongation factor 2 kinase by AMP-activated protein kinase. Cell Signal. 2017 Aug;36:212-221.

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