| Bioactivity | AMC-01 is a potent chemical probe that regulates eIF2-α activity. AMC-01 induces protein kinase RNA activation (PKR) kinase and nuclear factor κb (NF-κB). AMC-01 inhibits apoptosis[1]. |
| Invitro | AMC-01 (25 μM, 2 h) 对 Thapsigargin (HY-13433) 诱导的大鼠神经祖细胞 CSM14.1 凋亡具有抑制作用[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> AMC-01 相关抗体: Western Blot Analysis[1] Cell Line: |
| CAS | 1047978-71-1 |
| Formula | C27H27BrN2O6 |
| Molar Mass | 555.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hong MN, et al. The small molecule '1-(4-biphenylylcarbonyl)-4-(5-bromo-2-methoxybenzyl) piperazine oxalate' and its derivatives regulate global protein synthesis by inactivating eukaryotic translation initiation factor 2-alpha. Cell Stress Chaperones. 2016 May;21(3):485-97. |