| Bioactivity | AM-4668 is a GPR40 agonist for type 2 diabetes. EC50s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CHO cells (GPR40 aequorin assay), respectively[1]. | ||||||||||||
| Target | EC50: 3.6 nM (GPR40, in A9 cells), 36 nM (GPR40, in CHO cells) | ||||||||||||
| Name | AM-4668 | ||||||||||||
| CAS | 1011531-27-3 | ||||||||||||
| Formula | C24H19F3N2O4S | ||||||||||||
| Molar Mass | 488.48 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Liu JJ, et al. Optimization of GPR40 Agonists for Type 2 Diabetes. ACS Med Chem Lett. 2014 Feb 6;5(5):517-21. |
AM-4668
CAS: 1011531-27-3 F: C24H19F3N2O4S W: 488.48
AM-4668 is a GPR40 agonist for type 2 diabetes. EC50s of 3.6 nM and 36 nM for GPR40 in A9 cells (GPR40 IP3 assay) and CH
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