| Bioactivity | ALA-A2 is an anticancer peptide discovered in alpha-lactalbumin that selectively kills cancer cells by inducing Autophagy. ALA-A2 has cell-penetrating capabilities, allowing it to effectively enter cells without relying on membranolytic effects. In A549 lung cancer cells, ALA-A2 demonstrates significant dose-dependent anticancer activity. ALA-A2 holds promise for research in cancer therapy and autophagy regulation[1]. |
| Sequence | Lys-Leu-Trp-Cys-Lys-Ser-Ser-Gln-Val-Pro-Gln-Ser-Arg |
| Shortening | KLWCKSSQVPQSR |
| Formula | C67H111N21O19S |
| Molar Mass | 1546.79 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Lerksuthirat T, et al. ALA-A2 Is a Novel Anticancer Peptide Inspired by Alpha-Lactalbumin: A Discovery from a Computational Peptide Library, In Silico Anticancer Peptide Screening and In Vitro Experimental Validation. Glob Chall. 2023 Jan 12;7(3):2200213. |