| Bioactivity | AI-10-47 is a small molecule inhibitor of CBFβ-RUNX binding, with an IC50 of 3.2 μM[1]. |
| Invitro | AI-10-47 (10 μM) weakly inhibits CBFβ-RUNX binding[1].AI-10-47 significantly inhibits ME-1, TUR, M0-91, THP-1 and U937 cell growth[1]. Western Blot Analysis[1] Cell Line: |
| Name | AI-10-47 |
| CAS | 1256094-31-1 |
| Formula | C13H8F3N3O |
| Molar Mass | 279.22 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Anuradha Illendula, et al. Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers. EBioMedicine. 2016 Jun;8:117-131. |