AHR agonist 3_product_DataBase

Bioactivity	AHR agonist 3 is an aryl hydrocarbon receptor (AhR) agonist, that can induces cell cycle arrest or apoptosis via activation of tumor-suppressive transcriptional programs. AHR agonist 3 inhibits triple-negative breast cancer (TNBC) stem cell growth via AhR while exhibits minimal cytotoxicity against normal human primary cells and can be used for cancer research[1].
Invitro	AHR agonist 3 (Analog 523) (10 nΜ; 24 hour or 2-3 weeks) 可诱导 AhR WT 和 AhR KO 的 MDA-MB-468 细胞周期停滞并抑制克隆生成[1]。AHR agonist 3 (0-10 μΜ; 72 小时) 可使乳腺癌细胞，而非正常乳腺上皮细胞或非致瘤细胞发生 AhR 依赖性凋亡和生长抑制，并通过 AhR 抑制 TNBC 干细胞生长[1]。 Cell Proliferation Assay[1] Cell Line:
Name	AHR agonist 3
CAS	23749-58-8
Formula	C18H10N2O
Molar Mass	270.28
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Elson DJ, et.al. Induction of Aryl Hydrocarbon Receptor-Mediated Cancer Cell-Selective Apoptosis in Triple-Negative Breast Cancer Cells by a High-Affinity Benzimidazoisoquinoline. ACS Pharmacol Transl Sci. 2023 Jun 7;6(7):1028-1042.

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