| Bioactivity | AD186 is a potent and selective S1R agonist with Kis of 2.7, 27 nM for S1R and S2R, respectively. AD186 fully reverses the antiallodynic effect of BD-1063 (HY-18101A)[1]. |
| In Vivo | AD186 (compound 4b) (2.5-10 mg/kg; s.c.) 完全逆转 BD-1063 (HY-18101A) 在小鼠辣椒素诱导的机械超敏反应中的抗痛觉过敏作用[1]。 |
| Name | AD186 |
| Formula | C22H28N2 |
| Molar Mass | 320.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dichiara M, et al. Synthesis, Computational Insights, and Evaluation of Novel Sigma Receptors Ligands. ACS Chem Neurosci. 2023 May 17;14(10):1845-1858. |