| Bioactivity | AChE/BChE-IN-20 (compound 3m) is an acetylcholinesterase (AChE, IC50=34.81 µM) and butylcholinesterase (BChE, IC50=20.66 µM) inhibitor, which has been demonstrated to have affinity for key enzyme pockets and favorable interaction profiles by molecular docking and kinetic simulations, and can be used in the study of Alzheimer's disease[1]. |
| Formula | C20H20Cl2N4O6 |
| Molar Mass | 483.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Loori S, et al. Synthesis of novel aryl-substituted 2-aminopyridine derivatives by the cascade reaction of 1, 1-enediamines with vinamidinium salts to develop novel anti-Alzheimer agents[J]. Scientific Reports, 2024, 14(1): 13780. |