| Bioactivity | AChE-IN-28 (Compound 2h) is a selective slow-binding inhibitor of acetylcholinesterase with an IC50 of 0.2 nM[1]. |
| In Vivo | AChE-IN-28 (Compound 2h) (0.005-0.1 mg/kg; i.p.; single dose) 改善大鼠重症肌无力症状。AChE-IN-28 在小鼠中的 LD50 为 10 mg/kg (i.p.)[1]。 Animal Model: |
| Name | AChE-IN-28 |
| Formula | C33H48BrF3N5O4 |
| Molar Mass | 715.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Saifina LF, et al. Novel slow-binding reversible acetylcholinesterase inhibitors based on uracil moieties for possible treatment of myasthenia gravis and protection from organophosphate poisoning. Eur J Med Chem. 2022 Nov 24;246:114949. |