ABCG2-IN-3_product_DataBase

Bioactivity	ABCG2-IN-3 (Compound 52) is a selective inhibitor for breast cancer resistance protein (ABCG2), with an IC50 of 0.238 µM. ABCG2-IN-3 reverses the ABCG2-mediated resistance toward SN-38 and inhibit the ATPase activity[1].
Invitro	ABCG2-IN-3 对细胞 MDCK II BCRP 和 MDCK 野生型具有细胞毒性，CI50s 分别为 5.82 和 6.55 μM[1]。ABCG2-IN-3 抑制 ATPase，IC50 为 0.038 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> ABCG2-IN-3 相关抗体:
CAS	1942919-63-2
Formula	C25H20Cl2N2O2
Molar Mass	451.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Spindler A, et al., Synthesis and Investigation of Tetrahydro-β-carboline Derivatives as Inhibitors of the Breast Cancer Resistance Protein (ABCG2). J Med Chem. 2016 Jul 14;59(13):6121-35.

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