| Bioactivity | ABBV-4083 is an analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity[1]. |
| In Vivo | ABBV-4083 (150 mg/kg, once daily for 14 days) reduces Wolbachia levels (measured 16 weeks post-treatment-initiation, pti) in mice by >99.9% in the recovered female adult worms. Levels of circulating microfilariae declines from ~7 weeks pti and are completely cleared from 12 weeks pti until the end of this study at 16 weeks pti[1]. Animal Model: |
| Name | ABBV-4083 |
| CAS | 1809266-03-2 |
| Formula | C53H82FNO17 |
| Molar Mass | 1024.21 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. von Geldern TW, et al. Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity. PLoS Negl Trop Dis. 2019 Feb 28;13(2):e0007159. |