| Bioactivity | AA29504 is a ethyl carbamate with γ-aminobutyric acid (GABAA(HY-L120) receptor activity. AA29504 inhibits the delivery of the neurotransmitter gamma-aminobutyric acid in the central nervous system. AA29504 can be used to research anxiety, insomnia and other neuropsychiatric diseases [1]. |
| Invitro | AA29504 (0.1, 1, 10, 100 μM, 72 h) 在非洲爪蟾卵母细胞中可开启 Kv7 电压门控钾离子 (KCNQ) 通道[1]。AA29504 (1 μM) 对在非洲爪蟾卵母细胞中表达的GABAA受体有正向调节作用, EC501.4 μM[1]。AA29504 (1 μM, 10 s) 在前额叶皮层锥体神经元中对加波沙朵 (gaboxadol) 诱导的电流有显著增强作用[1]。 0 --> AA29504 相关抗体: |
| In Vivo | AA29504 (0.5, 2 或 4 mg/kg, 皮下注射) 在雄性 SD (Spraguee Dawley) 大鼠中有抗焦虑作用[1]。 AA29504 (4 mg/kg, 皮下注射)在乙醇的协同作用下显著减弱了雄性 SD 大鼠的运动协调性[1]。AA29504 (10 mg/kg, 皮下注射)在雄性维斯塔大鼠中对杏仁核点燃的癫痫发作有治疗作用[1]。 Animal Model: |
| Name | AA29504 |
| CAS | 945828-50-2 |
| Formula | C19H25N3O2 |
| Molar Mass | 327.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hoestgaard-Jensen K, et al. Pharmacological characterization of a novel positive modulator at alpha 4 beta 3 delta-containing extrasynaptic GABA(A) receptors. Neuropharmacology. 2010 Mar-Apr;58(4-5):702-11. |