| Bioactivity | A457 is a PKR2 antagonist, with an IC50 of 102 nM. A457 can rescue the cell surface expression and function of P290S PKR2, but not W178S and G234D PKR2[1]. |
| Invitro | A457 (1 μM, 16 h) 增加了细胞表面 P290S PKR2 的表达并恢复其功能。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> A457 相关抗体: |
| CAS | 1233923-95-9 |
| Formula | C26H33ClN2O3 |
| Molar Mass | 457.00 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dan-Na Chen, et al. Functional rescue of Kallmann syndrome-associated prokineticin receptor 2 (PKR2) mutants deficient in trafficking. J Biol Chem. 2014 May 30;289(22):15518-26. |