| Bioactivity | A-65282 is an antibacterial agent. A-65282 inhibits P4 DNA unknotting with an IC50 value of 8 µg/mL. A 65281 induces DNA breakage mediated by calf thymus topoisomerase II[1]. |
| CAS | 135906-72-8 |
| Formula | C17H16F2N4O2S |
| Molar Mass | 378.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kohlbrenner WE, et al. Induction of calf thymus topoisomerase II-mediated DNA breakage by the antibacterial isothiazoloquinolones A-65281 and A-65282. Antimicrob Agents Chemother. 1992 Jan;36(1):81-6. |
A-65282
CAS: 135906-72-8 F: C17H16F2N4O2S W: 378.40
A-65282 is an antibacterial agent. A-65282 inhibits P4 DNA unknotting with an IC50 value of 8 µg/mL. A 65281 induces DN
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