| Bioactivity | 8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK59 could penetrate and label living cells. BodipyFL-alkyne is coupled to the azide of 8RK64 (HY-148254) using copper(I)-mediated click chemistry, resulting in compound 8RK59[1]. |
| Target | UCHL1 (ubiquitin C-terminal hydrolase L1) |
| Invitro | 8RK59 (5 μM, 24 h) 仅与野生型 UCHL1 结合，但不与催化失活的 UCHL1 结合，表明探针结合位点是活性位点半胱氨酸[1]。 |
| Name | 8RK59 |
| CAS | 2705841-53-6 |
| Formula | C33H39BF2N10O2S |
| Molar Mass | 688.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kooij R, et al. Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. |
8RK59
CAS: 2705841-53-6 F: C33H39BF2N10O2S W: 688.60
8RK59, a Bodipy probe, is a potent UCHL1 (ubiquitin C-terminal hydrolase L1) inhibitor, with an IC50 close to 1 μM. 8RK
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