| Bioactivity | 7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR receptor EBI2 (GPR183). 7α, 25-dihydroxycholesterol is highly potent at activating EBI2 (EC50=140 pM; Kd=450 pM). 7α, 25-dihydroxycholesterol can serve as a chemokine directing migration of B cells, T cells and dendritic cells[1][2]. | |||||||||
| Invitro | In vitro, 7α, 25-dihydroxycholesterol (7α,25-OHC) stimulates the migration of EBI2-expressing mouse B and T cells with half-maximum effective concentration values around 500 pM, but had no effect on EBI2-deficient cells[1]. | |||||||||
| Name | 7α,25-Dihydroxycholesterol | |||||||||
| CAS | 64907-22-8 | |||||||||
| Formula | C27H46O3 | |||||||||
| Molar Mass | 418.65 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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7α,25-Dihydroxycholesterol
CAS: 64907-22-8 F: C27H46O3 W: 418.65
7α, 25-dihydroxycholesterol (7α,25-OHC) is a potent and selective agonist and endogenous ligand of the orphan GPCR rec
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