6-Iodopravadoline TFA_product_DataBase

Bioactivity	6-Iodopravadoline (AM630) TFA is a selective cannabinoid CB2 receptor antagonist (Ki=31.2 nM) that displays 165-fold selectivity over CB1 receptors. 6-Iodopravadoline TFA attenuates the ability of a number of cannabinoids to inhibit electrically-evoked twitches of the mouse isolated vas deferens[1][2].
In Vivo	6-Iodopravadoline (AM630) (2, 3 mg/kg, i.p.; Swiss ICR mice) TFA significantly reduces the time spent in the light box compared with vehicle group. 6-Iodopravadoline (AM630) (1, 2 or 3 mg/kg, i.p., twice a day; Swiss ICR mice) TFA produces a significant anxiolytic effect, increasing the time spent in the light box at all of the doses used[3].
Name	6-Iodopravadoline TFA
Formula	C25H26F3IN2O5
Molar Mass	618.38
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. García-Gutiérrez MS, et al. Chronic blockade of cannabinoid CB2 receptors induces anxiolytic-like actions associated with alterations in GABA(A) receptors. Br J Pharmacol. 2012;165(4):951-964. [2]. Pertwee R, et al. AM630, a competitive cannabinoid receptor antagonist. Life Sci. 1995;56(23-24):1949-1955.

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