| Bioactivity | 5-LOX-IN-2, an inhibitor of 5-lipoxygenase (5-LOX) with an IC50 of 0.33 μM, inhibits 5-LOX in a dose-dependent manner . 5-LOX-IN-2, reduces the cell viability of renal cancer cells and induces apoptosis, can be used for cancer research[1]. |
| Invitro | 5-LOX-IN-2 (Compound 10b) (0-100 μM；4 天) 能降低肾癌细胞的活力，对缺乏 Von Hippel-Lindau (VHL) 抑癌基因的 RCC4 和 786.0 细胞更具选择性[1]。 5-LOX-IN-2 (Compound 10b) (0-10 μM；24 小时) 能够增加 LC3B 和 p62 的表达，阻断 RCC4 细胞的自噬通量，通过激活 caspase-3 途径诱导细胞凋亡介导细胞死亡[1]。 Cell Viability Assay[1] Cell Line: |
| Name | 5-LOX-IN-2 |
| CAS | 179691-97-5 |
| Formula | C17H16O4 |
| Molar Mass | 284.31 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Selka A, et.al. Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells. Eur J Med Chem. 2019 Oct 1;179:347-357. |