4′-Demethylnobiletin_product_DataBase

Bioactivity	4′-Demethylnobiletin is a bioactive metabolite that activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment associated with NMDA receptor antagonism by stimulating ERK signaling[1].
Invitro	4′-Demethylnobiletin(1-100 μM, 0-60 min) 可以以时间和浓度依赖性的方式激活大鼠海马神经元中 ERK 和 CREB 的磷酸化，并以 PKA/MEK/ERK 途径依赖的方式，同时也可以通过激活 PKA/MEK/ERK 依赖信号通路刺激 CRE 介导的转录[1]。
In Vivo	4′-Demethylnobiletin (10 or 50 mg/kg, ip, once daily for seven consecutive days)在雄性 ddY 小鼠中可以剂量依赖性地逆转了 MK-801 诱导的学习障碍，而不影响小鼠的活动能力。其中用 MK-801 处理的小鼠比对照组小鼠表现出更少的冻结，并诱导小鼠的海马体中的 ERK 学习激活抑制，而 4′-Demethylnobiletin 也可以逆转该行为[1]。4′-Demethylnobiletin (10 or 50 mg/kg, ip, once daily for seven consecutive days)可以逆转 MK-801 对海马神经元中 NMDA 刺激的 ERK 和 PKA 底物磷酸化的抑制[1]。
Name	4′-Demethylnobiletin
CAS	34810-62-3
Formula	C20H20O8
Molar Mass	388.37
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Md Al Rahim, et al. 4'-Demethylnobiletin, a bioactive metabolite of nobiletin enhancing PKA/ERK/CREB signaling, rescues learning impairment associated with NMDA receptor antagonism via stimulation of the ERK cascade. Biochemistry. 2009 Aug 18;48(32):7713-21.

PeptideDB

4′-Demethylnobiletin

CAS: 34810-62-3 F: C20H20O8 W: 388.37