HDAC1/MAO-B-IN-1_product_DataBase

Bioactivity	HDAC1/MAO-B-IN-1 is a potent, selective and cross the blood-brain barrier HDAC1/MAO-B inhibitor with IC50 values of 21.4 nM and 99.0 nM for HDAC1 and MAO-B, respectively. HDAC1/MAO-B-IN-1 has the potential for the research of Alzheimer’s disease[1].
Invitro	HDAC1/MAO-B-IN-1 (compound 1f) shows inhibitory activities with IC50s of 99.0 nM, 9923.0 nM, 21.4 nM for hMAO-B, hMAO-A, hHDAC1, respectively[1].HDAC1/MAO-B-IN-1 (50 µM; 24 h) displays neuroprotective and inhibitory activity on ROS production in PC12 cells[1]. Cell Viability Assay[1] Cell Line:
In Vivo	HDAC1/MAO-B-IN-1 (20 mg/kg; i.g.) exhibits favorable BBB (blood–brain barrier) permeability[1].HDAC1/MAO-B-IN-1 (15 mg/kg; i.p.) improves the learning and memory abilities of the ICR mice[1]. Animal Model:
Name	HDAC1/MAO-B-IN-1
CAS	2759855-37-1
Formula	C18H17ClN2O2
Molar Mass	328.79
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yao C, et al. HDAC1/MAO-B dual inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation of N-propargylamine-hydroxamic acid/o-aminobenzamide hybrids. Bioorg Chem. 2022; 122:105724.

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