| Bioactivity | 4 '-DTMP is a DHFR inhibitor with Ki of 5.1 nM (DHFRWT) and 34.3 nM (DHFRL28R), respectively. 4 '-DTMP carries a polar modification that induces additional local interactions with the enzyme. In particular, the hairpin structure on the M20 ring is related to the internal communication of the DHFR. 4 '-DTMP has potential inhibition of E.coli[1]. | ||||||||||||
| Target | Ki: 5.1 nM (WT), 34.3 nM (L28R) | ||||||||||||
| Name | 4′-DTMP | ||||||||||||
| CAS | 21253-58-7 | ||||||||||||
| Formula | C13H16N4O3 | ||||||||||||
| Molar Mass | 276.29 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Cetin E, et al. Kinetic Barrier to Enzyme Inhibition Is Manipulated by Dynamical Local Interactions in E. coli DHFR. J Chem Inf Model. 2023 Aug 14;63(15):4839-4849. |