| Bioactivity | 4'-Chlorodiazepam (Ro 5-4864), a benzodiazepine derivative of Diazepam, is a potent mitochondrial translocator protein 18kDa (TSPO) ligand. 4'-Chlorodiazepam shows neuroprotective effects[1][2]. | |||||||||
| Invitro | 4'-Chlorodiazepam is neuroprotective against amyloid-beta (Aβ) in SHSY-5Y neuroblastoma cells. Aβ decreases the cell viability of organotypic hippocampal cultures, while 4'-Chlorodiazepam has a neuroprotective effect when administered at 100nM and 1000nM. The neuroprotective effects of 4'-Chlorodiazepam against Aβ are associated with an increased expression of superoxide dismutase (SOD) [1].4'-Chlorodiazepam preserves cell viability and reduces nuclear fragmentation in glucose-deprived cells. These effects are accompanied by a reduced production of free radicals and maintenance of mitochondrial functions in cells treated with 4'-Chlorodiazepam[2]. | |||||||||
| Name | 4'-Chlorodiazepam | |||||||||
| CAS | 14439-61-3 | |||||||||
| Formula | C16H12Cl2N2O | |||||||||
| Molar Mass | 319.19 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. B D Arbo, et al. 4'-Chlorodiazepam is neuroprotective against amyloid-beta in organotypic hippocampal cultures. J Steroid Biochem Mol Biol. 2017 Jul;171:281-287. [2]. Eliana Baez, et al. 4'-Chlorodiazepam Protects Mitochondria in T98G Astrocyte Cell Line from Glucose Deprivation. Neurotox Res. 2017 Aug;32(2):163-171. |
4'-Chlorodiazepam
CAS: 14439-61-3 F: C16H12Cl2N2O W: 319.19
4'-Chlorodiazepam (Ro 5-4864), a benzodiazepine derivative of Diazepam, is a potent mitochondrial translocator protein 1
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