3-epi-25-Hydroxy Vitamin D3-d6_product_DataBase

Bioactivity	3-epi-25-Hydroxy Vitamin D3-d6is the deuterium labeled3-epi-25-Hydroxy Vitamin D3(HY-142140)[1]. 3-epi-25-Hydroxy Vitamin D3 is the vitamin D metabolite, while vitamin D metabolism highly dependent on macrophage polarization. The C3-epimerase pathway for vitamin D is active in macrophages[2].
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。
Name	3-epi-25-Hydroxy Vitamin D3-d6
CAS	2483831-27-0
Formula	C27H38D6O2
Molar Mass	406.67
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Nygaard RH, et al'. Metabolism of 25-Hydroxy-Vitamin D in Human Macrophages Is Highly Dependent on Macrophage Polarization. Int J Mol Sci. 2022 Sep 19;23(18):10943.

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