| Bioactivity | 3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthritic effects. 3'-Sialyllactose sodium is an ordinary carbohydrate with the lowest toxicity rating, it can be used for the research of inflammation[1][2][3]. |
| Invitro | 3'-Sialyllactose sodium (0-250 μM; 24-36 h) promotes and restores Col2a1 synthesis and accumulates extracellular sulphated proteoglycan, and inhibits the effect of inflammatory cytokines[1].3'-Sialyllactose sodium (0-250 μM; 24 h) activates the expression of Sox9 and inhibits NF-κB activation in chondrocytes[1].3'-Sialyllactose sodium (0-5000 μg/plate) shows no mutagenic effect with no evident growth inhibition and deposition in all strains in the presence or absence of metabolic activation[3].3'-Sialyllactose sodium (1250 μg/mL) induces no chromosomal aberrations and shows non-clastogenic effect in either the presence or absence of metabolic activation[3]. Western Blot Analysis[1] Cell Line: |
| In Vivo | 3'-Sialyllactose sodium (10-100 mg/kg; p.o. three times a week for 6 weeks) protects mice against cartilage destruction from osteoarthritis[1].3'-Sialyllactose sodium (500, 1000 and 2000 mg/kg; oral administration; once) induces no micronuclei in the bone marrow cells of mice[3].3'-Sialyllactose sodium (oral administration; (500 to 1000 to 2000 mg/kg) every dose at 4-day intervals) shows the maximum tolerance dose (MTD) is greater than 2000 mg/kg in male and female beagle dogs[3].3'-Sialyllactose sodium shows a lethal dose (LD50) above 20 g/kg bw, the highest dose tested[3]. Animal Model: |
| Name | 3'-Sialyllactose sodium |
| CAS | 128596-80-5 |
| Formula | C23H38NNaO19 |
| Molar Mass | 655.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jeon J, et al. 3'-Sialyllactose protects against osteoarthritic development by facilitating cartilage homeostasis. J Cell Mol Med. 2018 Jan;22(1):57-66. [2]. Kang LJ, et al. 3'-Sialyllactose prebiotics prevents skin inflammation via regulatory T cell differentiation in atopic dermatitis mouse models. Sci Rep. 2020 Mar 27;10(1):5603. [3]. Kim D, et al. Toxicological evaluation of 3'-sialyllactose sodium salt. Regul Toxicol Pharmacol. 2018 Apr;94:83-90. |
3'-Sialyllactose sodium
CAS: 128596-80-5 F: C23H38NNaO19 W: 655.53
3'-Sialyllactose (3'-SL) sodium is a prebiotic, maintains immune homeostasis and exerts anti-inflammatory and anti-arthr
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