| Bioactivity | 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50≈65 nM) and selective suppressor of IgA production by B cells. | ||||||||||||
| Invitro | The synthesis of 25-hydroxycholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase, which uses cholesterol and molecular oxygen as substrates and NADPH as a cofactor. 25-hydroxycholesterol is a potent bioactive lipid in the innate and adaptive immune systems[1]. | ||||||||||||
| Name | 25-Hydroxycholesterol | ||||||||||||
| CAS | 2140-46-7 | ||||||||||||
| Formula | C27H46O2 | ||||||||||||
| Molar Mass | 402.65 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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25-Hydroxycholesterol
CAS: 2140-46-7 F: C27H46O2 W: 402.65
25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-li
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