| Bioactivity | 2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle. 2-Methylcitric acid trisodium accumulates in methylmalonic and propionic acidemias and acts as a marker metabolite. 2-Methylcitric acid trisodium markedly inhibits ADP-stimulated and uncoupled respiration in mitochondria supported by glutamate[1]. |
| Invitro | 2-Methylcitric acid trisodium impairs glutamate metabolism and induces permeability transition in brain mitochondria[1].2-Methylcitric acid trisodium inhibits glutamate dehydrogenase (GDH) activity at concentrations as low as 0.5 mM[1].2-Methylcitric acid trisodium (1 mM, 3 mM; 150 seconds) provokes a significant decrease in mitochondrial membrane potential and induced swelling in Ca2+-loaded mitochondria supported by different substrates[1].2-Methylcitric acid trisodium behaves as a potent inhibitor of glutamate oxidation by inhibiting glutamate dehydrogenase activity and as a permeability transition inducer, disturbing mitochondrial energy homeostasis[1].2-Methylcitric acid trisodium does not significantly impair mitochondrial glutamate transport[1].2-Methylcitric acid trisodium does not significantly impair glutamate mitochondrial transport in liver mitochondria[1]. |
| Name | 2-Methylcitric acid trisodium |
| CAS | 117041-96-0 |
| Formula | C7H7Na3O7 |
| Molar Mass | 272.10 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
2-Methylcitric acid trisodium
CAS: 117041-96-0 F: C7H7Na3O7 W: 272.10
2-Methylcitric acid trisodium (Methylcitric acid trisodium) is an endogenous metabolite in the 2-methylcitric acid cycle
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