2'-Deoxyadenosine-5'-triphosphate-15N5,d14 dilithium_product_DataBase

Bioactivity	2'-Deoxyadenosine-5'-triphosphate-15N5,d14 (dATP-15N5,d14) dilithium is deuterium and 15N labeled 2'-Deoxyadenosine-5'-triphosphate (HY-136648). 2'-Deoxyadenosine-5'-triphosphate (dATP) is a nucleotide used in cells for DNA synthesis (or replication), as a substrate of DNA polymerase.
Invitro	氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。 0 --> 2'-Deoxyadenosine-5'-triphosphate-15N5,d14 dilithium 相关抗体:
Name	2'-Deoxyadenosine-5'-triphosphate-15N5,d14 dilithium
Formula	C10D14Li215N5O12P3
Molar Mass	522.10
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. P J Romaniuk, A study of the mechanism of T4 DNA polymerase with diastereomeric phosphorothioate analogues of deoxyadenosine triphosphate. J Biol Chem. 1982 Jul 10;257(13):7684-8.

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