| Bioactivity | 2-Bromohexadecanoic acid (2-Bromopalmitic acid) can be converted to 2-bromopalmitate (2-BP). 2-BP is a palmitoylation inhibitor targeting DHHC (Asp-His-His-Cys) protein palmitoyltransferase. 2-BP inhibits palmitoylation of GSDME-C during pyroptosis and inhibits BAK/BAX-Caspase 3-GSDME pathway-mediated pyroptosis[1]. | ||||||||||||
| Invitro | 棕榈酰化促进 GSDME-N 在切割后释放 GSDME-C，2-BP 抑制棕榈酰化过程，而抑制 GSDME-C 的修饰，增加了 GSDME-C 和 GSDME-N 之间的相互作用。2-BP 抑制 TNFa+CHX 诱导的细胞凋亡，但不抑制细胞总死亡[1]。 | ||||||||||||
| Name | 2-Bromohexadecanoic acid | ||||||||||||
| CAS | 18263-25-7 | ||||||||||||
| Formula | C16H31BrO2 | ||||||||||||
| Molar Mass | 335.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hu L, et al. Chemotherapy-induced pyroptosis is mediated by BAK/BAX-caspase-3-GSDME pathway and inhibited by 2-bromopalmitate. Cell Death Dis. 2020 Apr 24;11(4):281. |
2-Bromohexadecanoic acid
CAS: 18263-25-7 F: C16H31BrO2 W: 335.32
2-Bromohexadecanoic acid (2-Bromopalmitic acid) can be converted to 2-bromopalmitate (2-BP). 2-BP is a palmitoylation in
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