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mTOR inhibitor WYE-28

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Bioactivity mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR>/b< (IC50)=0.08 nM. mTOR inhibitor WYE-28 inhibits PI3Kα with an IC50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T1/2) in nude mouse microsomes of 13 min[1].
Name mTOR inhibitor WYE-28
CAS 1062172-60-4
Formula C30H34N8O5
Molar Mass 586.64
Appearance Solid
Transport Room temperature in continental US; may vary elsewhere.
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Reference [1]. Zask A, et al. ATP-competitive inhibitors of the mammalian target of rapamycin: design and synthesis of highly potent and selective pyrazolopyrimidines. J Med Chem. 2009 Aug 27;52(16):5013-6.

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